Spontaneous activity of pacemaker cells

Authors

  • A. Pinchuk
  • Yu. Levchook
  • N. Chepelevskaja
  • Leonid Grechko

Keywords:

pacemaker cell, main cations, oscillations

Abstract

The mathematical model of spontaneous activity of a pacemaker cell has been considered. The cell authorhythmisity is reached by including in the model of five integral currents: potassium, calcium and sodium channels, sodium–potassium pump and sodium–calcium exchanger. The dynamics of changing of intracellular concentrations of main cations: K+, Na+, Ca2+, responsible for the spontaneous cell activity, have been obtained. The simulation of a membrane action potential and ionic currents was performed. The limit cycle oscillations were studied using phase diagram techniques.

How to Cite

Pinchuk, A., Levchook, Y., Chepelevskaja, N., & Grechko, L. (2001). Spontaneous activity of pacemaker cells. Physics of Consciousness and Life, Cosmology and Astrophysics, 1(1), 51–61. Retrieved from https://physics.socionic.info/index.php/physics/article/view/239

Issue

Section

Articles