Spontaneous activity of pacemaker cells

A. Pinchuk, Yu. Levchook, N. Chepelevskaja, Leonid Grechko


The mathematical model of spontaneous activity of a pacemaker cell has been considered. The cell authorhythmisity is reached by including in the model of five integral currents: potassium, calcium and sodium channels, sodium–potassium pump and sodium–calcium exchanger. The dynamics of changing of intracellular concentrations of main cations: K+, Na+, Ca2+, responsible for the spontaneous cell activity, have been obtained. The simulation of a membrane action potential and ionic currents was performed. The limit cycle oscillations were studied using phase diagram techniques.


pacemaker cell; main cations; oscillations


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